BDBM400102 (1aR,6aR)-5-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclobutyl)amino)-2-oxoacetyl)-N-(2-(difluoromethyl)-3-fluoropyridin-4-yl)-4-methyl-1,1a,6,6a-tetrahydrocyclopropa[b]pyrrolizine-3-carboxamide ::US10328053, Compound 80

SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CC3C[C@H]3n2c1C(=O)Nc1ccnc(C(F)F)c1F

InChI Key InChIKey=JXSOCXJUUDMOLB-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 400102   

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400102(US10328053, Compound 80 | (1aR,6aR)-5-(2-((3,3-dif...)
Affinity DataEC50:  8.70nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent