BDBM402028 5-[[5-[4-[[(3S)-1-ethylpyrrolidin-3-yl]oxymethyl]-2-methoxy-phenyl]1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile hydrochloride::US10010547, Example 138::US10973817, Example 138

SMILES CCN1CC[C@@H](C1)OCc1ccc(-c2cc(Nc3cnc(cn3)C#N)n[nH]2)c(OC)c1

InChI Key InChIKey=MVEBXCYXGNVESS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402028   

TargetSerine/threonine-protein kinase Chk1(Human)
Sentinel Oncology

US Patent
LigandPNGBDBM402028(US10010547, Example 138 | 5-[[5-[4-[[(3S)-1-ethylp...)
Affinity DataIC50: 0.0410nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required cofactors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Sentinel Oncology

US Patent
LigandPNGBDBM402028(US10010547, Example 138 | 5-[[5-[4-[[(3S)-1-ethylp...)
Affinity DataIC50: 0.0410nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent