BDBM406770 2-(6-aminopyridin-2-yl)-N-(3-fluoropyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine::US10336761, Example 53

SMILES Nc1cccc(n1)-c1nc(Nc2ccncc2F)c2cccn2n1

InChI Key InChIKey=JKONJOCLCQGBTA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406770   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 406770BDBM406770(2-(6-aminopyridin-2-yl)-N-(3-fluoropyridin-4-yl)py...)
Affinity DataIC50: 1.60nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 406770BDBM406770(2-(6-aminopyridin-2-yl)-N-(3-fluoropyridin-4-yl)py...)
Affinity DataIC50: 2.32E+3nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent