BDBM406985 3-fluoro-N-[5-({[2-(piperazin-1-yl)ethyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine::US10336761, Example 269

SMILES Fc1cnccc1Nc1nc(nn2ccc(CNCCN3CCNCC3)c12)-c1ccccn1

InChI Key InChIKey=MLHTXKHVGRWUAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406985   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406985(3-fluoro-N-[5-({[2-(piperazin-1-yl)ethyl]amino}met...)
Affinity DataIC50: 4.20nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406985(3-fluoro-N-[5-({[2-(piperazin-1-yl)ethyl]amino}met...)
Affinity DataIC50: 3.00E+3nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent