BDBM408743 US10358436, Example A157

SMILES CN1CCN(CC1)c1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cn1

InChI Key InChIKey=DMLLOBHOZFRIEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408743   

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM408743(US10358436, Example A157)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandPNGBDBM408743(US10358436, Example A157)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent