BDBM409248 2-[3-Chloro-6-[3-(difluoromethyl)phenyl]pyrrolo[3,2-b]pyridin-1-::US10377753, Example 150

SMILES CN(C)C(=O)Cn1cc(Cl)c2ncc(cc12)-c1cccc(c1)C(F)F

InChI Key InChIKey=CDXXGYBOTBOLGG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 409248   

LigandPNGBDBM409248(2-[3-Chloro-6-[3-(difluoromethyl)phenyl]pyrrolo[3,...)
Affinity DataIC50: 50nMAssay Description:Modulation of recombinant human GluN1/GluN2B NMDA receptor expressed in mammalian cells assessed as inhibition of glutamate/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM409248(2-[3-Chloro-6-[3-(difluoromethyl)phenyl]pyrrolo[3,...)
Affinity DataIC50: 50.1nMAssay Description:The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent