BDBM409969 2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro[3.3]heptane-2-carbonyl]-3H-1-benzazepine-4-carboxamide::US10370338, Example 1

SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2(C1)CN(C2)c1ccc(C)cc1

InChI Key InChIKey=UYGXGOQQIREFSM-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 409969   

TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM409969(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM409969(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Affinity DataEC50:  5nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM409969(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Affinity DataEC50: >100nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM409969(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Affinity DataEC50: >1.00E+5nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent