BDBM411494 US10392376, Example 46a::US10392376, Example 46b::US10800769, Example 46b::US11434233, Example 46a
SMILES C[C@@H]1COCCN1c1cc(N=[S@](C)(=O)C2CC2)nc(-c2ccnc3[nH]ccc23)n1
InChI Key InChIKey=HNEHJZKGHYOXGG-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 411494
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 1nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 1nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 8nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 8nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 8nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas
US Patent
University Of Texas
US Patent
Affinity DataIC50: 8nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human full-length FLAG-TEV-tagged ATR/His6-tagged ATRIP expressed in HEK293 cells using FAM-labeled RAD17 peptide and ATP as substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 179nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 179nMAssay Description:Inhibition of ATR in 4-NQO treated human HT-29 cells assessed as inhibition of Chk1 phosphorylation at Ser345 residue incubated for 90 mins followed ...More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 324nMAssay Description:Inhibition of mTOR (unknown origin) by LANCE Ultra assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of mTOR in human HT-29 cells assessed as inhibition of S6 ribosomal protein phosphorylation at Ser 235/236 residue incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoSimilars