BDBM411509 Methyl((6-((R)-3- methylmorpholino)-2- (1H-pyrrolo[2,3-b]- pyridin-4-yl)pyrimidin-4- yl)imino)(oxetan-3-yl)- lambda6-sulfanone::US10392376, Example 60::US10800769, Example 60

SMILES C[C@@H]1COCCN1c1cc(N=S(C)(=O)C2COC2)nc(-c2ccnc3[nH]ccc23)n1

InChI Key InChIKey=NXOLIFWGYRQEFT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 411509   

TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 411509BDBM411509(US10392376, Example 60 | Methyl((6-((R)-3- methylm...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human full-length FLAG-TEV-tagged ATR/His6-tagged ATRIP expressed in HEK293 cells using FAM-labeled RAD17 peptide and ATP as substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 411509BDBM411509(US10392376, Example 60 | Methyl((6-((R)-3- methylm...)
Affinity DataIC50: 4nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 411509BDBM411509(US10392376, Example 60 | Methyl((6-((R)-3- methylm...)
Affinity DataIC50: 4nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
The University of Texas MD Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 411509BDBM411509(US10392376, Example 60 | Methyl((6-((R)-3- methylm...)
Affinity DataIC50: 41nMAssay Description:Inhibition of ATR in 4-NQO treated human HT-29 cells assessed as inhibition of Chk1 phosphorylation at Ser345 residue incubated for 90 mins followed ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 411509BDBM411509(US10392376, Example 60 | Methyl((6-((R)-3- methylm...)
Affinity DataIC50: 41nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 411509BDBM411509(US10392376, Example 60 | Methyl((6-((R)-3- methylm...)
Affinity DataIC50: 307nMAssay Description:Inhibition of mTOR (unknown origin) by LANCE Ultra assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Texas MD Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 411509BDBM411509(US10392376, Example 60 | Methyl((6-((R)-3- methylm...)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of mTOR in human HT-29 cells assessed as inhibition of S6 ribosomal protein phosphorylation at Ser 235/236 residue incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed