BDBM412735 2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10399987, Example 2

SMILES Fc1cnccc1Nc1nc(-c2cccc(C(F)F)n2)nc2[nH]ccc12

InChI Key InChIKey=WTZAWAYSHRQGOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412735   

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 412735BDBM412735(US10399987, Example 2 | 2-(6-(difluoromethyl)pyrid...)
Affinity DataIC50: 0.25nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 412735BDBM412735(US10399987, Example 2 | 2-(6-(difluoromethyl)pyrid...)
Affinity DataIC50: 740nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent