BDBM413842 4-({(2S)-2-[4-{5-Chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5-methoxy-2-oxopyridin-1(2H)-yl]butanoyl}amino)-2-fluorobenzamide (Enantiomer 2)::US10421742, Example 235::US11180471, Example 235::US20250051303, Example 1
SMILES CC[C@@H](C(=O)Nc1ccc(C(N)=O)c(F)c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1-n1cc(nn1)C(F)(F)F
InChI Key InChIKey=XYWIPYBIIRTJMM-UHFFFAOYSA-N
Data 31 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 413842
Affinity DataIC50: 0.920nMAssay Description:The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...More data for this Ligand-Target Pair
Affinity DataIC50: 0.920nMAssay Description:FXIa: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting fin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.920nMAssay Description:The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...More data for this Ligand-Target Pair
Affinity DataIC50: 0.920nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of FXIa (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of FXIa (unknown origin) measured after 40 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of Factor XIa (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FXIa using p-Glu-Pro-Arg-pNA.HCl as substrate incubated for 30 mins followed by substrate addition and measured after 60 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human plasma Kallikrein using H-Pro-Phe-Arg-AMC as substrate measured after 40 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Factor XIa using Boc-Glu(OBzl)-Ala-Arg-AMC assessed as AMC release preincubated for 15 mins followed by substrate addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:To determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the reac...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:In the thrombin generation assay according to Hemker, the activity of thrombin plasma is determined by measuring the fluorescent cleavage products of...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Plasma Kallikrein: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of plasma Kallikrein (unknown origin) in buffer measured after 40 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of PKal (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of Pka (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human Pka in bufferMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of PKal (unknown origin) using H-D-Pro-Phe-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of FXIa (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human PKa using H-Pro-Phe-Arg-AMC as substrate incubated for 15 mins by fluorescence reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tPA (unknown origin) using H-D-Ile-Pro-Arg-pNA-2HCl as substrate incubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of plasmin (unknown origin) using PyroGlu-Phe-Lys-pNA.HCl as substrate incubated for 30 mins followed by substrate addition and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-Ile-Glu(gamma-OR)-Gly-Arg-pNA.HCl as substrate incubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of thrombin (unknown origin) using H-D-Phe-Pip-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FXa (unknown origin) using Z-D-Arg-Gly-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FXIIa (unknown origin) using H-D-ProPhe-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of chymotrypsin (unknown origin) using N-Suc-Ala-Ala-Pro-Phe-pNA as substrate incubated for 30 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of human Pka in human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of human trypsin using Boc-Ile-Glu-Gly-Arg-AMC as substrate incubated for 15 mins by fluorescence reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.27E+3nMAssay Description:Inhibition of human thrombin using Boc-Asp(OBzl)-Pro-Arg-AMC as substrate incubated for 15 mins by fluorescence reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.21E+3nMAssay Description:Inhibition of human Factor Xa using Boc-Ile-Glu-Gly-Arg-AMC as substrate incubated for 15 mins by fluorescence reader analysisMore data for this Ligand-Target Pair