BDBM414092 N-((1R,5S,8R)-3-((R)-6- (6-chloro-1H-pyrrolo[2,3- b]pyridin-4-yl)-7-methyl- 5,6,7,8-tetrahydropyrido- [4,3-d]pyrimidin-4-yl)-3- azabicyclo[3.2.1]- octan-8-yl)cyclopropane- sulfonamide::US10421765, Example 78::US10745420, Example 78

SMILES C[C@@H]1Cc2ncnc(N3C[C@@H]4CC[C@H](C3)[C@@H]4NS(=O)(=O)C3CC3)c2CN1c1cc(Cl)nc2[nH]ccc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414092   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414092(N-((1R,5S,8R)-3-((R)-6- (6-chloro-1H-pyrrolo[2,3- ...)
Affinity DataIC50:  184nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM414092(N-((1R,5S,8R)-3-((R)-6- (6-chloro-1H-pyrrolo[2,3- ...)
Affinity DataIC50:  184nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent