BDBM417368 US10457654, Example 227

SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Br)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=XZIIYADHVARGOG-BUKVSMQUSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417368   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM417368(US10457654, Example 227)
Affinity DataIC50:  1.19nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM417368(US10457654, Example 227)
Affinity DataIC50:  0.690nMAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Following the procedure described in Example 243A, and making modificati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent