BDBM4177 1,6-naphthyridin-2(1H)-one deriv. 7j::3-(2,6-Dichlorophenyl)-1-methyl-7-[[5-(4-methylpiperazin-1-yl)pentyl]amino]-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-1-methyl-7-{[5-(4-methylpiperazin-1-yl)pentyl]amino}-1,2-dihydro-1,6-naphthyridin-2-one

SMILES CN1CCN(CCCCCNc2cc3n(C)c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)CC1

InChI Key InChIKey=IARQDYQVYMTLQW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4177   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM4177(3-(2,6-dichlorophenyl)-1-methyl-7-{[5-(4-methylpip...)
Affinity DataIC50: 35nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM4177(3-(2,6-dichlorophenyl)-1-methyl-7-{[5-(4-methylpip...)
Affinity DataIC50: 110nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandPNGBDBM4177(3-(2,6-dichlorophenyl)-1-methyl-7-{[5-(4-methylpip...)
Affinity DataIC50: 9.90E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed