BDBM41949 (E)-2-cyano-3-(1-phenyl-3-thiophen-2-yl-4-pyrazolyl)-N-prop-2-enyl-2-propenamide::(E)-2-cyano-3-(1-phenyl-3-thiophen-2-yl-pyrazol-4-yl)-N-prop-2-enyl-prop-2-enamide::(E)-2-cyano-3-(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)-N-prop-2-enylprop-2-enamide::(E)-N-Allyl-2-cyano-3-(1-phenyl-3-thiophen-2-yl-1H-pyrazol-4-yl)-acrylamide::(E)-N-allyl-2-cyano-3-[1-phenyl-3-(2-thienyl)pyrazol-4-yl]acrylamide::MLS000588327::SMR000212142::cid_1902746

SMILES N1(C=NC=C1)C1=CC=C(C=N1)/C=C/C=1C=NC(=NC1)N1C[C@@H](N(CC1)C1=NC=C(C=N1)CF)COC

InChI Key InChIKey=HTSQIHHCUYPOOO-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 41949   

TargetAlpha-synuclein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 41949BDBM41949((R,E)-5-(2-(6-(1H-imidazol-1-yl)pyridin-3-yl)vinyl...)
Affinity DataKi:  1.10nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent

TargetAmyloid-beta precursor protein(Human)
8932 Hightail Drive

WIPO
LigandChemical structure of BindingDB Monomer ID 41949BDBM41949((R,E)-5-(2-(6-(1H-imidazol-1-yl)pyridin-3-yl)vinyl...)
Affinity DataKi:  1.20E+4nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent