BDBM419919 US10472364, Compound 5::US10570167, Cpd. # 5::US11034715, Cpd. # 5::US11208414, Cpd. # 5

SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F

InChI Key InChIKey=DDBYNIDRHBNGHN-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 419919   

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419919(US10472364, Compound 5 | US10570167, Cpd. # 5 | US...)
Affinity DataIC50: 1.31E+4nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419919(US10472364, Compound 5 | US10570167, Cpd. # 5 | US...)
Affinity DataIC50: 1.31E+4nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419919(US10472364, Compound 5 | US10570167, Cpd. # 5 | US...)
Affinity DataIC50: 1.31E+4nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2021
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419919(US10472364, Compound 5 | US10570167, Cpd. # 5 | US...)
Affinity DataIC50: 1.31E+4nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetCD99 antigen(Homo sapiens)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM419919(US10472364, Compound 5 | US10570167, Cpd. # 5 | US...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to N-terminal biotin-tagged recombinant human CD99 extracellular domain (23 to 122 residues) expressed in Escherichia coli BL21(DE3)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCD99 antigen(Homo sapiens)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM419919(US10472364, Compound 5 | US10570167, Cpd. # 5 | US...)
Affinity DataKd:  2.47E+3nMAssay Description:Binding affinity to N-terminal biotin-tagged recombinant human CD99 extracellular domain (23 to 122 residues) expressed in Escherichia coli BL21(DE3)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed