BDBM42041 (R,E)-(1-(5-(2-(6-(1H-imidazol-1-yl)pyridin-3-yl)vinyl)pyrimidin-2-yl)-4-(6-fluoropyrimidin-4-yl)piperazin-2-yl)methanol::WO2024186584, Example 15

SMILES N1(C=NC=C1)C1=CC=C(C=N1)/C=C/C=1C=NC(=NC1)N1[C@H](CN(CC1)C1=NC=NC(=C1)F)CO

InChI Key InChIKey=LGKQKELVYYSUHI-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 42041   

TargetAlpha-synuclein(Human)
Galderma Research & Development

US Patent
LigandChemical structure of BindingDB Monomer ID 42041BDBM42041((R,E)-(1-(5-(2-(6-(1H-imidazol-1-yl)pyridin-3-yl)v...)
Affinity DataKi:  1nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Galderma Research & Development

US Patent
LigandChemical structure of BindingDB Monomer ID 42041BDBM42041((R,E)-(1-(5-(2-(6-(1H-imidazol-1-yl)pyridin-3-yl)v...)
Affinity DataKi:  1.20E+4nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
US Patent