BDBM423185 N-[(5R)-1-Amino-3-methyl-5H,6H,7H-cyclopenta[c]pyridin-5-yl]-1-[(6-{3-azabicyclo[3.1.0]hexan-3-yl}-2-methylpyridin-3-yl)methyl]-3-methyl-1H-pyrazole-4-carboxamide::US10501440, Example 15

SMILES COc1ccc(CNc2nc(C)cc3[C@@H](CCc23)NC(=O)c2cn(Cc3ccc(nc3C)N3CC4CC4C3)nc2C)c(OC)c1

InChI Key InChIKey=PQXOFAKBCRDHCR-FJGWTWLBSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 423185   

TargetPlasma kallikrein(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423185(N-[(5R)-1-Amino-3-methyl-5H,6H,7H-cyclopenta[c]pyr...)
Affinity DataKi:  0.400nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Rattus norvegicus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423185(N-[(5R)-1-Amino-3-methyl-5H,6H,7H-cyclopenta[c]pyr...)
Affinity DataIC50:  0.5nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent