BDBM423198 US10501449, Example 1-I

SMILES Cc1cc(ncc1C#N)-n1cc(CN2CCO[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1

InChI Key InChIKey=HWABUIBUCAPVSQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 423198   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423198(US10501449, Example 1-I)
Affinity DataIC50: 11nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 3 to 8 mins by whole cell manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423198(US10501449, Example 1-I)
Affinity DataIC50: 11nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423198(US10501449, Example 1-I)
Affinity DataIC50: 14nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed