BDBM423212 US10501449, Example 83-I

SMILES C[C@H]1CN(Cc2cnn(n2)-c2cc(C)c(cn2)C#N)C[C@H](N1)c1ccc2C(=O)OCc2c1C

InChI Key InChIKey=NRCYDDLRPFXMNA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 423212   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 6.80nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 3 to 8 mins by whole cell manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 24nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPOU domain, class 2, transcription factor 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of OCT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMultidrug and toxin extrusion protein 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of MATE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPOU domain, class 2, transcription factor 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of OCT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBile salt export pump(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInward rectifier potassium channel 13(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kir 7.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetATP-sensitive inward rectifier potassium channel 10(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kir 4.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInward rectifier potassium channel 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kir 2.3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInward rectifier potassium channel 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kir 2.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of OAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of MRP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/bile acid cotransporter(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of NTCP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSolute carrier organic anion transporter family member 1B3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of OATP1B3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of BCRP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlycerol-3-phosphate phosphatase(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of PGP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423212(US10501449, Example 83-I)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed