BDBM423231 6-(4-(((3R,4R)-4- hydroxy-3-(4- methyl-1-oxo-1,3- dihydroisobenzofur- an-5-yl)piperidin-1- yl)methyl)-1H- pyrazol-1-yl)-4- methylnicotinonitrile::US10501449, Example 110-I

SMILES Cc1cc(ncc1C#N)-n1cc(CN2CC[C@@H](O)[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1

InChI Key InChIKey=OBXNXAOEDFSFFT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 423231   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423231(6-(4-(((3R,4R)-4- hydroxy-3-(4- methyl-1-oxo-1,3- ...)
Affinity DataIC50: 16nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423231(6-(4-(((3R,4R)-4- hydroxy-3-(4- methyl-1-oxo-1,3- ...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 3 to 8 mins by whole cell manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423231(6-(4-(((3R,4R)-4- hydroxy-3-(4- methyl-1-oxo-1,3- ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed