BDBM423263 4-methyl-6-(4-((2- methyl-5-(4-methyl-1- oxo-1,3- dihydroisobenzofuran- 5-yl)piperazin-1- yl)methyl)-1H-pyrazol- 1-yl)nicotinonitrile Enantiomer-II)::US10501449, Example 244-II

SMILES CC1CNC(CN1Cc1cnn(c1)-c1cc(C)c(cn1)C#N)c1ccc2C(=O)OCc2c1C

InChI Key InChIKey=AAWRZXNVPSFVQM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 423263   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423263(4-methyl-6-(4-((2- methyl-5-(4-methyl-1- oxo-1,3- ...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423263(4-methyl-6-(4-((2- methyl-5-(4-methyl-1- oxo-1,3- ...)
Affinity DataIC50: 22nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM423263(4-methyl-6-(4-((2- methyl-5-(4-methyl-1- oxo-1,3- ...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 3 to 8 mins by whole cell manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed