BDBM42332 (R)-2-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-5-((2-(4-(5-fluoropyridin-2-yl)-3-(methoxymethyl)piperazin-1-yl)pyrimidin-5-yl)ethynyl)pyrimidine::WO2024186584, Example 85

SMILES FCCN1N=CC(=C1)C1=NC=C(C=N1)C#CC=1C=NC(=NC1)N1C[C@@H](N(CC1)C1=NC=C(C=C1)F)COC

InChI Key InChIKey=XHTRLCPNADNBMI-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 42332   

TargetAlpha-synuclein(Human)
Galderma Research & Development

US Patent
LigandChemical structure of BindingDB Monomer ID 42332BDBM42332((R)-2-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-5-((2-(4...)
Affinity DataKi:  1.05nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
US Patent