BDBM425892 N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- methyl-1H-benzimidazole- 5-carboxamide::US10512634, Example 228

SMILES COc1c(C)cc(cc1C)-c1nc2cc(ccc2n1C)C(=O)NO

InChI Key InChIKey=OSGRTKLGYQMZMK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 425892   

TargetHistone deacetylase 6(Homo sapiens (Human))
Kancera

US Patent
LigandPNGBDBM425892(N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- met...)
Affinity DataIC50:  3.5nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Kancera

US Patent
LigandPNGBDBM425892(N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- met...)
Affinity DataIC50:  2.00E+3nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Kancera

US Patent
LigandPNGBDBM425892(N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- met...)
Affinity DataIC50:  100nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Kancera

US Patent
LigandPNGBDBM425892(N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- met...)
Affinity DataIC50:  216nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Kancera

US Patent
LigandPNGBDBM425892(N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- met...)
Affinity DataIC50:  3.5nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Kancera

US Patent
LigandPNGBDBM425892(N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- met...)
Affinity DataIC50:  2.00E+4nMAssay Description:All Examples were tested in HDAC1, 2, 3, 6 and 8 in vitro enzymatic assays. The assay principle is well known (Hauser et al. 2009, Bradner et al. 201...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent