BDBM426021 US10513518, Example 11

SMILES Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)CC2)C3=O)ccc2c1COC2=O

InChI Key InChIKey=OKLZGZLAIKNUEF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 426021   

LigandChemical structure of BindingDB Monomer ID 426021BDBM426021(US10513518, Example 11)
Affinity DataIC50: 11nMAssay Description:Inhibition of human ROMK expressed in CHO cells by whole cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 426021BDBM426021(US10513518, Example 11)
Affinity DataIC50: 122nMAssay Description:1. Seed HEK-hKir1.1 cells (50 μl at 20,000 cells/well) in 384-well PDL coated Microplates2. Allow cells to adhere overnight in humidified 37° C....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 426021BDBM426021(US10513518, Example 11)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed