BDBM429525 3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-methyl-N-(methylsulfonyl)-1H-indole-6-carboxamide::US10550080, Example 42

SMILES CC(C)COc1ncc(cc1Cl)-c1cn(C)c2cc(C(=O)NS(C)(=O)=O)c(F)cc12

InChI Key InChIKey=FVUIYPLOVITXKN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 429525   

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM429525(3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-me...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM429525(3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-me...)
Affinity DataIC50: 11nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM429525(3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-me...)
Affinity DataIC50: 520nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM429525(3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-me...)
Affinity DataIC50: 524nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429525(3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-me...)
Affinity DataIC50: 7.18E+3nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429525(3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-me...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed