BDBM429615 US10550091, No. LC-24::US10947203, No. LC-24
SMILES COc1cc(OC)c(cc1C)-n1nnc(c1C)S(=O)(=O)c1ccc(cc1)C(C)(C)C
InChI Key InChIKey=HXRSXIPYPZGCEK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 429615
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataIC50: 340nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataEC50: 880nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataIC50: 340nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataIC50: 750nMAssay Description:Binding affinity to human PXRMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataEC50: 280nMAssay Description:Agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by lucifer...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataEC50: 880nMAssay Description:Activation of human PXRMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children''S Research Hospital
US Patent
St. Jude Children''S Research Hospital
US Patent
Affinity DataEC50: 880nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair