BDBM429640 US10550091, No. LC-49::US10947203, No. LC-49

SMILES COc1ccc(OC)c(c1)-n1nnc(c1C#N)S(=O)(=O)c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=YDNGCXVICLTJOO-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 429640   

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM429640(US10550091, No. LC-49 | US10947203, No. LC-49)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM429640(US10550091, No. LC-49 | US10947203, No. LC-49)
Affinity DataIC50: 300nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM429640(US10550091, No. LC-49 | US10947203, No. LC-49)
Affinity DataIC50: 570nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM429640(US10550091, No. LC-49 | US10947203, No. LC-49)
Affinity DataIC50: 570nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM429640(US10550091, No. LC-49 | US10947203, No. LC-49)
Affinity DataIC50: 970nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM429640(US10550091, No. LC-49 | US10947203, No. LC-49)
Affinity DataIC50: 970nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM429640(US10550091, No. LC-49 | US10947203, No. LC-49)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed