BDBM430343 (R) or (S)-2-fluoro-N-[3-(1- hydroxyethyl)-7-phenylimidazo[1,2- a]pyridin-8-yl]-5-(1-methyl-1H-pyrazol- 3-yl)-4-(trifluoromethyl)benzamide::US10556900, Compound 25::US10556900, Compound 26

SMILES CC(O)c1cnc2c(NC(=O)c3cc(-c4ccn(C)n4)c(cc3F)C(F)(F)F)c(ccn12)-c1ccccc1

InChI Key InChIKey=FXDGJCQPOXEWBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430343   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM430343((R) or (S)-2-fluoro-N-[3-(1- hydroxyethyl)-7-pheny...)
Affinity DataIC50: 0.310nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM430343((R) or (S)-2-fluoro-N-[3-(1- hydroxyethyl)-7-pheny...)
Affinity DataIC50: 0.810nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent