BDBM430356 2-fluoro-N-[3-(1-hydroxy- 1-methylethyl)-6- phenylpyrazolo[1,5- a]pyridin-7-yl]-5- pyrimidin-2-yl-4- (trifluoromethyl)benzamide::US10556900, Compound 38

SMILES CC(C)(O)c1cnn2c(NC(=O)c3cc(-c4ncccn4)c(cc3F)C(F)(F)F)c(ccc12)-c1ccccc1

InChI Key InChIKey=AXFOBESGAZFYMT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430356   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM430356(2-fluoro-N-[3-(1-hydroxy- 1-methylethyl)-6- phenyl...)
Affinity DataIC50: 1.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent