BDBM431968 US10576064, Example I-86

SMILES Fc1c(Cl)cccc1[C@H]1[C@H]2[C@H](CCN(C2=O)c2ccc(cc2)C#N)N(CC2CC2)[C@@]11C(=O)Nc2cc(Cl)ccc12

InChI Key InChIKey=XBSZXJYQQZDTED-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431968   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 431968BDBM431968(US10576064, Example I-86)
Affinity DataIC50: 159nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent