BDBM431972 US10576064, Example I-112

SMILES CCOc1cccc(CN2[C@@H]3CCN(C(=O)[C@@H]3[C@@H](c3cccc(Cl)c3F)[C@@]22C(=O)Nc3cc(Cl)ccc23)c2ccc(cc2)C(=O)OC)c1

InChI Key InChIKey=VGSXOTBOORJFRS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431972   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 431972BDBM431972(US10576064, Example I-112)
Affinity DataIC50: 3.29E+3nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent