BDBM431997 US10576064, Example I-208

SMILES OC(=O)c1ccc(CN2CC[C@H]3[C@H]([C@H](c4cccc(Cl)c4F)[C@@]4(N3CC3CC3)C(=O)Nc3cc(Cl)ccc43)C2=O)cc1

InChI Key InChIKey=VWLYRWRTDYSBJB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431997   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 431997BDBM431997(US10576064, Example I-208)
Affinity DataIC50: 210nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent