BDBM433233 N-((1R,3r,5S)-8-((4-((4- cyanobenzyl)amino)piperidin-1- yl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)- 5-cyclopropylisoxazole-3-carboxamide::US10577363, Compound 938

SMILES O=C(N[C@@H]1C[C@@H]2CC[C@H](C1)N2S(=O)(=O)N1CCC(CC1)NCc1ccc(cc1)C#N)c1cc(on1)C1CC1

InChI Key InChIKey=GQKIVNAREIOALR-BKFWDETESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433233   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM433233(N-((1R,3r,5S)-8-((4-((4- cyanobenzyl)amino)piperid...)
Affinity DataIC50:  44.1nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent