BDBM435414 US10570116, Compound C22

SMILES COc1ncc(C(=O)C2CCN(C(=O)CC(C)(C)Cc3nc4c(cnn4C)c(=O)[nH]3)CC2)cc1C

InChI Key InChIKey=HEJKSHFADGJFLY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435414   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 435414BDBM435414(US10570116, Compound C22)
Affinity DataIC50: 1.80nMAssay Description:TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 435414BDBM435414(US10570116, Compound C22)
Affinity DataIC50: 2.20nMAssay Description:TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 435414BDBM435414(US10570116, Compound C22)
Affinity DataIC50: 3.00E+4nMAssay Description:PARP-1: The autoparsylation assay is performed as 384-well HTRF (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent