BDBM436681 6-(4-Fluorophenyl)-1-[(5-methylisoxazol-3-yl)methyl]-3H-imidazo[4,5- b]pyridin-2-one::US10617676, Example 12::US11207298, Example 12

SMILES CNC(=O)c1c(C)oc2cc(Oc3ccnn4cc(C(=O)N5CC(O)C5(C)C)c(C)c34)ccc12

InChI Key InChIKey=XBOYMQBHPFURQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436681   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436681BDBM436681((R or S)-6-((6-(3-hydroxy-2,2- dimethylazetidine-1...)
Affinity DataEC50:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent