BDBM436696 1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(trifluoromethyl)-2- thienyl]imidazo[4,5-b]pyridin-2-one::US10617676, Example 120::US10617676, Example 27::US11207298, Example 120

SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1ccc(s1)C(F)(F)F

InChI Key InChIKey=VBYDZMQKWHOANY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 436696   

TargetCytochrome P450 2D6(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436696BDBM436696(US10617676, Example 27 | US10617676, Example 120 |...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using nifedipine as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed