BDBM436774 6-(5-Cyclopropyl-2-thienyl)-1-[2-(3-fluoroazetidin-1-yl)-2-oxo-ethyl]-3- methyl-imidazo[4,5-b]pyridin-2-one::US10617676, Example 106::US11207298, Example 106

SMILES CO[C@H]1C[C@@H](NC(=O)c2c(C)oc3cc(Oc4ccnn5cc(C(=O)N6C[C@H](F)[C@H]6C)c(C)c45)ccc23)C1

InChI Key InChIKey=KGHCBOGJKCPXLM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436774   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436774BDBM436774(6-({6-[(2R,3S)-3-fluoro-2- methylazetidine-1-carbo...)
Affinity DataEC50:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent