BDBM436811 6-(3,4-Difluorophenyl)-1-[[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl]- 3H-imidazo[4,5-b]pyridin-2-one::US10617676, Example 145::US11207298, Example 145

SMILES C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N

InChI Key InChIKey=TXFYEMZQUNWIKN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436811   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436811BDBM436811(5-((1S,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorot...)
Affinity DataKd:  0.0230nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436811BDBM436811(5-((1S,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorot...)
Affinity DataKd:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436811BDBM436811(5-((1S,4S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorot...)
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent