BDBM436829 1-[2-(3-Fluoroazetidin-1-yl)ethyl]-6-[3-(trifluoromethyl)phenyl]-3H- imidazo[4,5-b]pyridin-2-one::US10617676, Example 163::US11207298, Example 163

SMILES Cn1nccc1C(=O)N1CC2(CCCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(-c5ccc(F)c6sc(N)c(C#N)c56)c(Cl)cc34)C2)C1

InChI Key InChIKey=JYHHOTUSZKRFFS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436829   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436829BDBM436829(5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetra...)
Affinity DataKd:  0.0270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436829BDBM436829(5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetra...)
Affinity DataKd:  0.180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436829BDBM436829(5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetra...)
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent