BDBM436832 1-[2-(3,3-Difluoroazetidin-1-yl)ethyl]-6-[3-(trifluoromethyl)phenyl]-3H- imidazo[4,5-b]pyridin-2-one::US10617676, Example 167::US11207298, Example 167

SMILES Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2

InChI Key InChIKey=BMIRSLDQJVAZHP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436832   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436832BDBM436832(5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetra...)
Affinity DataKd:  0.0280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436832BDBM436832(5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetra...)
Affinity DataKd:  0.170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436832BDBM436832(5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetra...)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent