BDBM436860 N-(3,3-Difluorocyclobutyl)-2-[2-oxo-6-[3-(trifluoromethyl)phenyl]-3H- imidazo[4,5-b]pyridin-1-yl]acetamide::US10617676, Example 195::US11207298, Example 195

SMILES C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4CC(F)(F)C5)nc(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)c3CO2)c2c1ccc(N)c2C#N

InChI Key InChIKey=JAEZJXWQBMISRL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436860   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436860BDBM436860(US20260022132, Compound 546a)
Affinity DataKd:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436860BDBM436860(US20260022132, Compound 546a)
Affinity DataKd:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436860BDBM436860(US20260022132, Compound 546a)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent