BDBM436872 1-[2-(2,6-Diazaspiro[3.3]heptan-6-yl)-2-oxo-ethyl]-6-[3- (trifluoromethyl)phenyl]-3H-imidazo[4,5-b]pyridin-2-one::US10617676, Example 207::US11207298, Example 207

SMILES C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45COC5)c3CO2)c2c1ccc(N)c2C#N

InChI Key InChIKey=AZYVONBJNRBHMF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436872   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436872BDBM436872((1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1...)
Affinity DataKd:  0.0480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436872BDBM436872((1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1...)
Affinity DataKd:  0.330nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436872BDBM436872((1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1...)
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent