BDBM436918 1-(Pyrazin-2-ylmethyl)-6-[3-(trifluoromethyl)phenyl]-3H-imidazo[4,5- b]pyridin-2-one::US10617676, Example 253::US11207298, Example 253

SMILES Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2

InChI Key InChIKey=PZAMDDZOGCICLL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436918   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436918BDBM436918(US20260022132, Compound 591a)
Affinity DataKd:  0.120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436918BDBM436918(US20260022132, Compound 591a)
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436918BDBM436918(US20260022132, Compound 591a)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent