BDBM436919 1-[(2-Methylpyrimidin-4-yl)methyl]-6-[3-(trifluoromethyl)phenyl]-3H- imidazo[4,5-b]pyridin-2-one::US10617676, Example 254::US11207298, Example 254

SMILES C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC4(CO)CO)c3CO2)c2c1ccc(N)c2C#N

InChI Key InChIKey=QUIRFFFDXSJZMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436919   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436919BDBM436919((1S,4S)-7-Amino-4'-(2,2-bis(hydroxymethyl)azetidin...)
Affinity DataKd:  0.0260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436919BDBM436919((1S,4S)-7-Amino-4'-(2,2-bis(hydroxymethyl)azetidin...)
Affinity DataKd:  0.170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436919BDBM436919((1S,4S)-7-Amino-4'-(2,2-bis(hydroxymethyl)azetidin...)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent