BDBM436980 1-[(3-Methyl-2-pyridyl)methyl]-6-[3-(trifluoromethyl)phenyl]-3H-imidazo[4,5- b]pyridin-2-one::US10617676, Example 315::US11207298, Example 315

SMILES CO[C@@H]1CN2CCC[C@]2(COc2nc3c(c(N4CCCn5nc(C(=O)N(C)C)c(Cl)c5C4)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1

InChI Key InChIKey=ITJIBZJLHQUXLR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436980   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436980BDBM436980(US20260022132, Compound 628c)
Affinity DataKd:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436980BDBM436980(US20260022132, Compound 628c)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent