BDBM437024 6-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-methyl-1-(3- pyridylmethyl)imidazo[4,5-b]pyridin-2-one::US10617676, Example 360::US11207298, Example 360

SMILES CO[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC[C@]45CCOC5)n2)CO[C@@]2(CC[C@H](C)c4ccc(N)c(C#N)c42)C3)C1

InChI Key InChIKey=OUAVTVNRJPCXJH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 437024   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 437024BDBM437024(US20260022132, Compound 654d)
Affinity DataKd:  0.180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 437024BDBM437024(US20260022132, Compound 654d)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent