BDBM437458 5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4-yl]- 1-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyridin-2-one::US10617680, Example 192::US11020380, Example 192

SMILES Cn1cc(cn1)-c1cc(=O)n(C)cc1-c1cnn(CC2CC2(F)F)c1

InChI Key InChIKey=AHQRRRNRQPVZDP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 437458   

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437458BDBM437458(5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437458BDBM437458(5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent