BDBM437552 4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl)- 1H-pyrazol-4-yl]-1-methyl-1H-pyridin-2-one::US10617680, Example 286::US11020380, Example 286

SMILES Cn1cc(-c2cnn(c2)-c2ccccc2S(C)(=O)=O)c(cc1=O)-c1ccc(Cl)cc1

InChI Key InChIKey=GNWGEXFCZAIQLR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 437552   

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437552BDBM437552(4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437552BDBM437552(4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437552BDBM437552(4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl...)
Affinity DataIC50: 500nMAssay Description:The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437552BDBM437552(4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BRD4 was determined as described previously. See, e.g., U.S. Pat. No. 9,034,900.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 437552BDBM437552(4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent