BDBM438366 (1-methyl-3,4-dihydro-isoquinolin-2(1H- yl-3-((2-methyl-thiazol-4-yl)ethynyl) phenyl)methanone::US10618900, No. ZD011

SMILES CC1N(CCc2ccccc12)C(=O)c1cccc(c1)C#Cc1csc(C)n1

InChI Key InChIKey=PUGJBPDDXSNEKC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 438366   

TargetMetabotropic glutamate receptor 5(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438366((1-methyl-3,4-dihydro-isoquinolin-2(1H- yl-3-((2-m...)
Affinity DataIC50: 3.26E+4nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent